AB0349 NEUTROPHIL-TO-LYMPHOCYTE RATIO, PLATELET-TO-LYMPHOCYTE RATIO AND MEAN PLATELET VOLUME IN LUPUS NEPHRITIS

Background: A number of blood count parameters are associated with inflammatory and autoimmune diseases. There is discordant evidence whether neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) mean platelet volume (MPV) might reflect response have prognostic value in SLE patients. However, the studies examining potential role these markers LN missing. Objectives: To examine NLR, PLR MPV at time biopsy patients evaluate their association prognosis. Methods: In this retrospective study we analyzed demographic, histologic, laboratory clinical characteristics biopsy-proven diagnosed between 2011 2020. All met 1997 revised American College Rheumatology classification criteria for SLE. Complete remission was defined as proteinuria <0.5 g/day serum creatinine within 10% from baseline, partial more than 50% reduction to sub-nephrotic levels baseline. Results: We included 55 (80% women) (age 38±13 years). On renal histology, one patient class I LN, two were II, 7 III, 5 III+V, 23 IV, IV+V, 11 VI 4 had other features. Median baseline NLR 3.64 (IQR: 1.85, 6.93), 167 116, 300) 10.0 9.2, 10.8). no differences any three different classess (all p>0.05). Eighteen achieved complete (CR), 16 21 did not achieve remission. None progressed ESRD died, both sepsis. group which CR/PR vs. p>0.05; Figure 1). constructed a thorough multivariate regression model showed that neither or predictors LN. Conclusion: useful predicting References: [1]Hartmann LT, et al. Open Rheumatol J. 2018 Aug 31;12:129-138. [2]Chen SY, J Res Med Sci. May 30;23:48. [3]Zhao CN, Int. Sep;38(9):1635-1641. Disclosure Interests: declared